NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Both exceeded the NNV in the general population (1840 best case 1196, worst case 3066). ![]() The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351 best case 196, worst case 816) or non-cancer surgery (733 best case 407, worst case 1664). NNVs were more favourable in surgical patients than the general population. Best- and worst-case scenarios were used to describe uncertainty. NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). ![]() ![]() The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Preoperative SARS-CoV-2 vaccination could support safer elective surgery.
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